At the Arkansas Children’s Hospital Research Institute, leaders in the field of autism spectrum disorders (ASDs) are conducting basic science, clinical, and translational research to help children affected by ASDs and their families. Our research works towards providing a deeper understanding of the psychological, behavioral, and physiological mechanisms that cause ASD and howto address these core problems to promote a chance at recovery and to establish optimal outcomes through targeted interventions. Current research projects include measuring the impact of oxidative stress, mitochondrial function, and environmental stressors on ASD as well as treatment studies to address these underlying issues that may give rise to behavioral dysregulations and medical symptoms associated with autism. The clinical program incorporates investigator-initiated and industry-sponsored clinical trials, development of an autism clinical diagnosis and care system, and collaborations with neurologists, psychiatrists, gastroenterologists, geneticists, and others. Together, these efforts strive to improve the development of novel behavioral and medical therapies to accelerate and optimize recovery of children diagnosed with ASD and to develop strategies for preventing ASD from developing in high-risk children.
Autism Translational Research Center
The Autism Translational Research Center conducts clinical trials of novel treatments for core symptoms of autism spectrum disorder, and discovering new biomarkers of autism.
Director - Richard Frye, MD, PhD
Co-Investigator - Jill James, PhD
Coordinator - Leanna Delhey(Telephone: 501-364-4519)
Currently Enrolling Clinical Trials
Mitochondrial Function in Health and Disease
We are studying the contribution of mitochondrial function on the development of neurologic and neurodevelopmental disorders. We are especially interested in how epilepsy interacts with mitochondrial function and neurodevelopmental disorder so we are looking for children who fall into the below categories with and without epilepsy.
1. Ages 0-17 years
2. One of the groups below with and without epilepsy
• Autism Spectrum Disorder
• Developmental Delay
• Mitochondrial Disorder
3. Typically Developing without any major medical problems.
1. Antipsychotic Medications
2. Prematurity (less than 34 weeks gestation)
One or Two Visits of approximately 3 hours each
Each Visit Involves
-Fasting Blood Draw
-First Morning Urine Collection
-Neuropsychological assessments of
-Collection of baby teeth, if available
Mileage and Per Visit Compensation Provided
Study Contact Name and Number
Study coordinator: John Slattery
Principal Investigator: Richard Frye